Alpha power modulation with tACS: a customized therapeutic approach

Abstract Among other electrophysiological biomarkers, power reduction in the alpha frequency band (8-12 Hz) is characteristic of Alzheimer’s Disease (AD). Restoring this could help improve performance related functional networks and cognitive state AD patients. Transcranial alternate current stimulation (tACS) stands as a promising tool regard, given its capacity to entrain neural activity at particular frequency. 27 healthy participants with ages ranging from (22 55 years/ 32.80 ± 8.52 ) were recruited for study. After being randomly assigned verum or sham group, each participant was stimulated through tACS Cz Oz electrodes his own Individual Alpha Frequency (IAF) 20 minutes. The neurophysiological initially captured by two successive 5-minute eyes-closed resting MEG recordings, 10-minute time interval between sessions. stimulation, third recording extracted measure effects. performing CBPT analysis, group showed an increase cluster bilateral frontal, temporal occipital cortical sources (p<0.01). Research Category Technology Methods Clinical Research: 5. Other Electrical Stimulation (tES) Keywords: tACS, MCI, Alfa, Neurostimulation